After exiting the bone marrow, reticulocytes mature to form red blood cells (RBCs). These are highly adapted cells able to survive for about 120 days in the circulation without getting a single protein renewed. RBCs constantly move and adapt to their surrounding by changing shapes, producing vasorelaxation, protecting the surrounding tissues from oxidative stress and adjusting oxygen delivery to the need. The project EVIDENCE (Erythrocytes properties and viability in dependence of flow and extra-cellular environment) brings together twelve partners from from the Academic institutions, clinics and companies of six European countries to study RBCs in flow. To do so microfluidic technologies, computational modelling and physiological tests will be applied to the cells that are born, thrive and are ready to die. Based on these observations the new technological approached will be suggested for diagnosis or rare anemias, prognosis and optimization of treatment strategies. Further advances are also expected in blood conservation technologies. Red Blood Cell Research Group at the University of Zurich will focus at the impact of redox state on RBC properties (deformability, stability, oxygen carrying capacity) in flow.
The early stage researcher (ESR) on this project will join the international network within the project.
According to the rules of the Marie Curie Actions, fostering mobility, the candidate should be from outside the host country (Switzerland) and ready to spend several months within the project at partner institutions.
This is an interdisciplinary project. It requires fair knowledge of the basics of physics and chemistry along with biology.
Basic skills in computational sciences is an advantage.
Profound knowledge of English is of key importance.
Knowledge of other foreign languages (German, French, Italian, Spanish, or Russian) is useful.
The work on the project is both demanding and rewarding. The ESRs will participate in interdisciplinary projects in the field of red blood cell research and will be introduced to European and American Red Blood Cell Societies, will receive personalized training in the area, and will join the imMed PhD training program of the Life Science Zurich Graduate School of the University if Zurich ending up in a PhD thesis defense at the Faculty of Science.
Duration of the project: 3 years. Foreseen starting date is January 1st2020.